Orthopoxvirus Vaccine Group Evaluation and Forecasting Rules
General Rules for Orthopoxvirus - EUA
General rules are not series-specific; general rules apply to the entire vaccine group.
If the patient has no shots on record, recommendation is Conditional with reason code HIGH_RISK.
Orthopoxvirus Vaccines
CVX Code | Name | Absolute Minimum Age |
|---|---|---|
751 | vaccinia (smallpox) vaccine (ACAM2000) | 1 year - 4 days |
1051 | vaccinia (smallpox) vaccine, diluted (Inactive; not preferred) | 1 year - 4 days |
2061 | Vaccinia, smallpox monkeypox vaccine live, PF (JYNNEOS) | 0 days |
Combination Vaccines that Include Orthopoxvirus
No combination vaccines exist, at this time, that include Orthopoxvirus.
CVX Code Specific Rules
- The Live Vaccine Interval rule is not enforced for evaluation of Orthopoxvirus - May 2022 EUA, but is considered for the forecast date.1
1 Information about dosing intervals for inadvertently administered doses below the minimum interval is available at https://www.cdc.gov/poxvirus/monkeypox/interim-considerations/jynneos-vaccine.html#dosing.
Immunization Series and Selection Rules - EUA
Series Name
- Monkeypox 2-Dose Series - EUA - May 2022
- Monkeypox 1-Dose Series - EUA - May 2022
Series Selection Rules
There are two series for this vaccine group: the Monkeypox 2-Dose Series and the Monkeypox 1-Dose Series. The rules for determining which series applies are:
If a CVX 75 or CVX 105 dose is administered for dose 1, the Orthopoxvirus 1-Dose Series (May 2022 EUA) applies.
If a CVX 206 dose is administered for dose 1, the Orthopoxvirus 2-Dose Series (May 2022 EUA) applies.
Immunization Series: Orthopoxvirus 2-Dose Series (May 2022 EUA)
The Orthopoxvirus 2-Dose Series - EUA - May 2022 is complete after 2 doses.
Vaccine Dose Parameters - Minimum and Routine Ages
Dose | Series Name | Absolute Minimum | Minimum Age | Routine | Latest Recommended Age (less than) | Valid CVX Code(s) per Dose for this Series | Invalid CVX Code(s) per Dose for this Series |
|---|---|---|---|---|---|---|---|
1 | Orthopoxvirus 2-Dose Series (May 2022 EUA) | 0 days | 18 years | 18 years | N/A | 206 | N/A |
2 | Orthopoxvirus 2-Dose Series (May 2022 EUA) | N/A | N/A | N/A | N/A | 206, 75, 105 | N/A |
Vaccine Dose Parameters - Minimum and Recommended Intervals
Doses | Series Name | Absolute Minimum Interval | Minimum Interval | Minimum Recommended Interval | Latest Recommended Interval (less than) |
|---|---|---|---|---|---|
Dose 1 to 2 | Orthopoxvirus 2-Dose Series (May 2022 EUA) | 0 days | 28 days | 28 days | 35 days |
Series Special Rules
Series Evaluation Special Rules
The series is complete after 2 doses.
If the 2nd shot is administered below the minimum interval or live virus interval, evaluate the shot as Valid with reason code SUPPLEMENTAL_TEXT and descriptive text: “The interval between this dose and the prior shot is less than the minimum interval. The dose does not need to be repeated unless the patient is severely immunosuppressed, in which case the repeated dose should be administered after the dose given in error by at least 28 days.”
If an additional shot is administered after the series is complete, evaluate it as Valid. Evaluate all additional shots afterwards as Accepted / EXTRA_DOSE.
Immunization Series: Orthopoxvirus 1-Dose Series (May 2022 EUA)
The Monkeypox 1-Dose Series - EUA - May 2022 is complete after 1 dose.
Vaccine Dose Parameters - Minimum and Routine Ages
Dose | Series Name | Absolute Minimum | Minimum Age | Routine | Latest Recommended Age (less than) | Valid CVX Code(s) per Dose for this Series | Invalid CVX Code(s) per Dose for this Series |
|---|---|---|---|---|---|---|---|
1 | Orthopoxvirus 1-Dose Series (May 2022 EUA) | 1 year - 4 days | N/A | N/A | N/A | 75, 105 | N/A |
Series Special Rules
Series Evaluation Special Rules
The series is complete after 1 dose.
If an additional shot is administered after the series is complete, evaluate it as Valid. Evaluate all additional shots afterwards as Accepted / EXTRA_DOSE.