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Dose

Series Name

Absolute Minimum
 Age

Minimum Age

Routine
Age 

Latest Recommended Age (less than)Valid CVX Code(s) per Dose for this SeriesInvalid CVX Code(s) per Dose for this Series

1

Hep B Newborn 

0 days

0 days

0 days

4 weeks08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189
N/A

2

Hep B Newborn 

24 days

28 days

2 months1 month1

3 months + 4 weeks08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189
N/A

3

Hep B Newborn 

164 days

168 days

6 months

19 months + 4 weeks08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189
N/A

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Doses

Series Name

Absolute Minimum Interval

Minimum Interval

Minimum Recommended Interval

Latest Recommended Interval (less than)

Dose 1 to 2

Hep B Newborn

24 days

28 days

N/A 2


5 months + 4 weeks

Dose 2 to 3

Hep B Newborn

52 days

56 days

56 days

18 months + 4 weeks

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Notes

  • The routine age for dose 2 in the table above (2 months)1 differs from the CDC CDSi routine age of 1 month.  The ICE Workgroup recommends 2 months as the routine recommended age for the following reasons:
    • Two months is a routine age for preventive care visits and the recommended age for several other vaccine groups.
    • If combination Hep B vaccines are used, these are not licensed before 6 weeks of age.
    • For a routine recommendation for a healthy child, it is not necessary to squeeze dose 2 in before 2 months of age.
    There is no recommended interval2 between dose 1 and 2 in the Newborn series because the routine age of 2 months must be met for the recommendation. Even if dose 1 is administered at 27 days of age, dose 2 would never be recommended 28 days later because the routine age of 2 months would not have been met.1 month)1 only applies for single-antigen HepB vaccines.

Immunization Series: Hep B 3-dose Child/Adult Series

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Notes

  • The absolute minimum age for dose 1 in the table above (24 28 days)1 does not include a 4-day grace period; it represents the minimum age for this series.

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