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Rules Based on Patient's Age
- If a patient is >= 19 60 years old and did NOT get a shot of Hep B, then the Recommendation is Conditional and the reason code is HIGH_RISK.
- Shots administered to a patient who is >= 19 60 years of age will continue to be evaluated and, if valid, will count toward completion of the series.
Proof of Immunity Rules- If a patient has immunity (reported as having a positive titer or serology) vaccine is not recommended.
- Any shot administered prior to the date of immunity is evaluated as Valid or Invalid, based on minimum age and minimum interval rules.
- Any shot administered on or after the date of immunity is evaluated as Accepted with a reason code of PROOF_OF_IMMUNITY; Recommendation is Not Recommended and the reason code is PROOF_OF_IMMUNITY.
Atkinson (Enough is Enough) Rule
- If a patient receives target dose 3 that is invalid (e.g. due to minimum interval violation or minimum age violation), there is no minimum interval between the next-to-last shot (invalid shot) and dose 3 (the final dose), but the patient must a.) meet the minimum interval between dose 2 and the final dose (52 days), b.) meet the minimum age for the final dose in the series (164 days), and c.) meet the minimum interval between dose 1 and dose 3 of 16 weeks.
- Example: Dose 1 at 28 days, dose 2 at 113 days, invalid shot 3 (target dose 3) at 163 days (below minimum age for the series and below minimum interval), shot 4/dose 3 at 165 days = series complete (even though there is only a 2-day interval between shot 3 and shot 4/dose 3), based on the Atkinson Rule.
- The Atkinson rule does not apply to recommendations; when determining the date due the recommended interval is calculated from the last shot given.
Select Adjuvant Product IntervalRules for Recommending at the CVX Code vs. Vaccine Group Level- When recommending in the Hep B 3-dose Newborn Series or , the Hep B 3-dose Child/Adult Adolescent Series, always or the Hep B 3-dose Adult Series, recommend at the vaccine group level.
- When recommending in the Hep B 2-dose Adult Series, always recommend at the CVX level; vaccine recommended should be CVX 189 (Hep B, adjuvanted).
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CVX Code | Name | Absolute Minimum Age | Absolute Maximum Age |
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08 | Hep B, adolescent or pediatric | 0 days | 20 years - 1 day |
42 | Hep B, adolescent/high risk infant | 0 days | 20 years - 1 day |
43 | Hep B, adult | 0 days | N/A |
44 | Hep B, dialysis | 0 days | N/A |
45 | Hep B, unspecified formulation | 0 days | N/A |
189 | Hep B, adjuvanted | 18 years - 4 days | N/A |
220 | Hep B recombinant | 18 years - 4 days | N/A |
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CVX Code Specific RulesCVX Code Maximum Age
- CVX 08 (Hep B, adolescent or pediatric) and CVX 42 (Hep B, adolescent/high risk infant) will be evaluated as follows:
- InvalidInvalid / INSUFFICIENT_ANTIGEN if INSUFFICIENT_ANTIGEN if administered to a patient who is >= 20 years old.
- Valid (as long as minimum interval/minimum age requirements are met, where applicable) if administered to a patient who is < 20 years old.
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CVX Code | Vaccine Name | Component CVX Code | Component Vaccine Name |
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51 | Hib-Hep B (Comvax) | 08 | Hep B, adolescent or pediatric |
110 | DTaP-Hep B-IPV (Pediarix) | 08 | Hep B, adolescent or pediatric |
104 | Hep A-Hep B (Twinrix) | 43 | Hep B, adult |
102 | DTP-Hib-Hep B | 45 | Hep B, NOS |
132 | DTaP-IPV-Hib-Hep B, historical | 08 | Hep B, adolescent or pediatric |
146 | DTaP, IPV, Hib, Hep B | 08 | Hep B, adolescent or pediatric |
Immunization Series and Selection Rules
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198 | DTP-Hep B-Hib, Pentavalent | 45 | Hep B, NOS |
Immunization Series and Selection Rules
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Series Name- Hep B 3-dose Newborn Series
- Hep B 3-dose Child/Adolescent Series
- Hep B 2-dose Adult Series
- Hep B 23-dose Adult Series
Series Selection Rules Rules for Determining When to Apply the Newborn Series vs. Child/Adolescent Series vs. Adult 2-Dose Series vs. Adult 3-Dose Series
- If the patient is <= 27 days old and has not received the first shot of Hep B, series = Hep B 3-dose Newborn seriesSeries.
- If the patient is <= 27 days old when they receive the first shot of Hep B, series = Hep B 3-dose Newborn seriesSeries.
- If the patient is >= 28 days old and has < 19 years old and has not received the first shot of Hep B, series = Hep B 3-dose Child/Adult seriesAdolescent Series.
- If the patient is >= 28 days old and < 19 years old or older when they receive the first shot of Hep B, series = Hep B 3-dose Child/Adult seriesAdolescent Series.
- If the patient is >= 18 years - 4 days and dose 1 is CVX 189:
Notes- The CDC CDSi rules and test cases utilize a
- if dose 1 was administered at < 19 years of age:
- and there are no other shots on record, series = Hep B 2-dose Adult
series- Series.
- and target dose 2 is invalid or accepted for the 2-dose Adult
series Adult series- Adolescent Series, series = Hep B 2-dose Adult
series- Series.
- and target dose 2 is valid for the 2-dose Adult Series, series = Hep B 2-dose Adult
series- Series.
- and there are >= 2 valid shots in the Child/
Adult - Adolescent Series, but < 2 valid shots in the 2-dose Adult Series, series = Hep B 3-dose Child/
Adult series- Adolescent Series.
- and there are 3 valid shots in the Child/
Adult - Adolescent Series and 2 valid shots in the 2-dose Adult Series and both series are completed on the same day, series = Hep B 3-dose Child/
Adult
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- if dose 1 was administered >= 19 years of age:
- and there are no other shots on record, series = Hep B 3-dose
primary series, which is a newborn series. ICE utilizes both a newborn series and a child/adult series.
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Immunization Series: Hep B 3-dose Newborn Series
The Hep B Newborn series is complete after 3 doses.
Vaccine Dose Parameters - Minimum and Routine Ages
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Dose
...
Series Name
...
Absolute Minimum
Age
...
Routine
Age
...
1
...
Hep B Newborn
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0 days
...
0 days
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2
...
Hep B Newborn
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24 days
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2 months1
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3
...
Hep B Newborn
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164 days
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6 months
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Vaccine Dose Parameters - Minimum and Recommended Intervals
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Doses
...
Series Name
...
Absolute Minimum Interval
...
Minimum Recommended Interval
...
Dose 1 to 2
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Hep B Newborn
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24 days
...
N/A 2
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Dose 2 to 3
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Hep B Newborn
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52 days
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56 days
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Series Special Rules HEPLISAV-B (CVX 189) Exception Rule- A series containing 2 doses of HEPLISAV-B (CVX 189) administered at least minimum interval 4 weeks (absolute minimum interval = 24 days) apart is complete, regardless of any other Hep B shots administered (before, in between). For the non-CVX 189 shots, evaluate as Accepted and the reason code is VACCINE_NOT_COUNTED_BASED_ON_MOST_RECENT_VACCINE_GIVEN. For the purpose of evaluation of the non-CVX 189 administered vaccines, ignore the non-CVX 189 shots.
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Notes- The routine age for dose 2 in the table above (2 months)1 differs from the CDC CDSi routine age of 1 month. The ICE Workgroup recommends 2 months as the routine recommended age for the following reasons:
- Two months is a routine age for preventive care visits and the recommended age for several other vaccine groups.
- If combination Hep B vaccines are used, these are not licensed before 6 weeks of age.
- For a routine recommendation for a healthy child, it is not necessary to squeeze dose 2 in before 2 months of age.
- There is no recommended interval2 between dose 1 and 2 in the Newborn series because the routine age of 2 months must be met for the recommendation. Even if dose 1 is administered at 27 days of age, dose 2 would never be recommended 28 days later because the routine age of 2 months would not have been met.
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Immunization Series: Hep B 3-dose Child/Adult Series
The HepB Child/Adult series is complete after 3 doses, except when the Adolescent 2-Dose Series Rule applies.
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- Adult Series.
- and target dose 2 is invalid or accepted for the 2-dose Adult series or 3-dose Adult series series = Hep B 2-dose Adult Series.
- and target dose 2 is valid for the 2-dose Adult Series, series = Hep B 2-dose Adult Series.
- and there are >= 2 valid shots in the 3-dose Adult Series, but < 2 valid shots in the 2-dose Adult Series, series = Hep B 3-dose Adult Series.
- and there are 3 valid shots in the 3-dose Adult Series and 2 valid shots in the 2-dose Adult Series and both series are completed on the same day, series = Hep B 3-dose Adult Series.
- If the patient is >= 19 years old and < 60 years old and has not received the first shot of Hep B, series = Hep B 3-dose Adult Series.
- If the patient is >= 19 years old when they receive the first dose of Hep B and dose 1 is not CVX 189, series = Hep B 3-dose Adult Series.
- If the patient is >= 60 years old and receives an invalid shot for Target Dose 1, series = Hep B 3-dose Adult Series.
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Immunization Series: Hep B 3-dose Newborn Series
The Hep B 3-dose Newborn Series is complete after 3 doses.
Vaccine Dose Parameters - Minimum and Routine Ages
Dose | Series Name | Absolute Minimum Age | Minimum Age | Routine Age | Latest Recommended Age (less than) | Valid CVX Code(s) per Dose for this Series | Invalid CVX Code(s) per Dose for this Series |
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1 | Hep B 3-dose Newborn Series | 0 days | 0 days | 0 days | 4 weeks | 08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 198
| N/A |
2 | Hep B 3-dose Newborn Series | 24 days | 28 days | 1 month | 3 months + 4 weeks | 08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189, 198, 220
| N/A |
3 | Hep B 3-dose Newborn Series | 164 days | 168 days | 6 months | 19 months + 4 weeks | 08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189, 198, 220
| N/A |
Vaccine Dose Parameters - Minimum and Recommended Intervals
Doses | Series Name | Absolute Minimum Interval | Minimum Interval | Recommended Interval | Latest Recommended Interval (less than) |
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Dose 1 to 2 | Hep B 3-dose Newborn Series | 24 days | 28 days | 28 days | 5 months + 4 weeks |
Dose 2 to 3 | Hep B 3-Dose Newborn Series | 52 days | 56 days | 56 days | 18 months + 4 weeks |
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Series Special Rules HEPLISAV-B (CVX 189) Exception Rule- A series containing 2 doses of HEPLISAV-B (CVX 189) administered at least minimum interval 4 weeks (absolute minimum interval = 24 days) apart is complete, regardless of any other Hep B shots administered (before, in between). For the non-CVX 189 shots, evaluate as Accepted and the reason code is VACCINE_NOT_COUNTED_BASED_ON_MOST_RECENT_VACCINE_GIVEN. For the purpose of evaluation of the non-CVX 189 administered vaccines, ignore the non-CVX 189 shots.
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Immunization Series: Hep B 3-dose Child/Adolescent Series
The Hep B 3-dose Child/Adolescent Series is complete after 3 doses.
Vaccine Dose Parameters - Minimum and Routine Ages
Dose | Series Name | Absolute Minimum Age | Minimum Age | Routine Age | Latest Recommended Age (less than) | Valid CVX Code(s) per Dose for this Series | Invalid CVX Code(s) per Dose for this Series |
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1 | Hep B Child/Adult3-dose Child/Adolescent Series | 28 days1 | 28 days | 2 months | 3 months + 4 weeks | 08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189, 198, 220
| N/A |
2 | Hep B 3-dose Child/AdultAdolescent Series | 52 days | 56 days | 4 months | 5 months + 4 weeks | 08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189, 198, 220
| N/A |
3 | Hep B 3-dose Child/AdultAdolescent Series | 164 days | 168 days | 6 months | 19 months + 4 weeks | 08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189, 198, 220
| N/A |
Vaccine Dose Parameters - Minimum and Recommended Intervals
Doses | Series Name | Absolute Minimum Interval | Minimum Interval | Minimum Recommended Interval | Latest Recommended Interval (less than) |
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Dose 1 to 2 | Hep B 3-dose Child/AdultAdolescent Series | 24 days | 28 days | 28 days (4 weeks) | N/A |
Dose 2 to 3 | Hep B 3-dose Child/AdultAdolescent Series | 52 days | 56 days | 56 days (8 weeks) | N/A |
Dose 1 to 3 | Hep B 3-dose Child/AdultAdolescent Series | 108 days | 112 days | 112 days (16 weeks) | N/A |
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| Adolescent 2-Dose Series Rules
- If a.) CVX 43 (Hep B adult) is administered to a patient >= 11 years and < 16 years as dose 1 and dose 2 AND b.) there is a minimum interval of 4 months - 4 days between dose 1 and dose 2, THEN the series is complete with 2 doses. If this rule is not met, default to the Hep B 3-dose seriesChild/Adolescent Series.
- If a patient >= 11 years and < 16 years is administered CVX 43 (Hep B adult) as shot 1, shot 2 will be recommended based on the Hep B 3-dose Child/Adult seriesAdolescent Series, NOT the Adolescent 2-Dose Series Rule.
HEPLISAV-B (CVX 189) Exception Rule- A series containing 2 doses of HEPLISAV-B (CVX 189) administered at least minimum interval 4 weeks (absolute minimum interval = 24 days) apart is complete, regardless of any other Hep B shots administered (before, in between). For the non-CVX 189 shots, evaluate as Accepted and the reason code is VACCINE_NOT_COUNTED_BASED_ON_MOST_RECENT_VACCINE_GIVEN. For the purpose of evaluation of the non-CVX 189 administered vaccines, ignore the non-CVX 189 shots.
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Notes- The absolute minimum age for dose 1 in the table above (24 days)1 does not include a 4-day grace period; it represents the minimum age for this series.
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Immunization Series: Hep B 2-dose Adult Series
The HepB 2-dose Adult series is complete after 2 doses.
Vaccine Dose Parameters - Minimum and Routine Ages
...
Dose
...
Series Name
...
Absolute Minimum
Age
...
Routine
Age
...
1
...
Hep B 2-dose Adult
...
18 years - 4 days
...
18 years
...
2
...
Hep B 2-dose Adult
...
N/A
...
N/A
...
Vaccine Dose Parameters - Minimum and Recommended Intervals
...
Doses
...
Series Name
...
Absolute Minimum Interval
...
Minimum Recommended Interval
...
Dose 1 to 2
...
Hep B 2-dose Adult
...
24 days
...
28 days (4 weeks)
...
- For the purpose of evaluation of the non-CVX 189 administered vaccines, ignore the non-CVX 189 shots.
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Notes- The absolute minimum age for dose 1 in the table above (28 days)1 does not include a 4-day grace period; it represents the minimum age for this series.
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Immunization Series: Hep B 2-dose Adult Series
The Hep B 2-dose Adult Series is complete after 2 doses.
Vaccine Dose Parameters - Minimum and Routine Ages
Dose | Series Name | Absolute Minimum Age | Minimum Age | Routine Age | Latest Recommended Age (less than) | Valid CVX Code(s) per Dose for this Series | Invalid CVX Code(s) per Dose for this Series |
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1 | Hep B 2-dose Adult Series | 18 years - 4 days | 18 years | 18 years | 18 years | 189
| N/A |
2 | Hep B 2-dose Adult Series
| N/A | N/A | N/A | N/A | 189
| N/A |
Vaccine Dose Parameters - Minimum and Recommended Intervals
Doses | Series Name | Absolute Minimum Interval | Minimum Interval | Recommended Interval | Latest Recommended Interval (less than) |
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Dose 1 to 2 | Hep B 2-dose Adult Series | 24 days | 28 days | 28 days (4 weeks) | 56 days (8 weeks) |
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Series Special Rules HEPLISAV-B (CVX 189) Exception Rule - A series containing 2 doses of HEPLISAV-B (CVX 189) administered at least minimum interval 4 weeks (absolute minimum interval = 24 days) apart is complete, regardless of any other Hep B shots administered (before, in between). For the non-CVX 189 shots, evaluate as Accepted and the reason code is VACCINE_NOT_COUNTED_BASED_ON_MOST_RECENT_VACCINE_GIVEN. For the purpose of evaluation of the non-CVX 189 administered vaccines, ignore the non-CVX 189 shots.
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Immunization Series: Hep B 3-dose Adult Series
The Hep B 3-dose Adult Series is complete after 3 doses.
Vaccine Dose Parameters - Minimum and Routine Ages
Dose | Series Name | Absolute Minimum Age | Minimum Age | Routine Age | Latest Recommended Age (less than) | Valid CVX Code(s) per Dose for this Series | Invalid CVX Code(s) per Dose for this Series |
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1 | Hep B 3-dose Adult Series | 19 years | 19 years | 19 years | N/A | 08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189, 198, 220 | N/A |
2 | Hep B 3-dose Adult Series
| N/A | N/A | N/A | N/A | 08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189, 198, 220 | N/A |
3 | Hep B 3-dose Adult Series | N/A | N/A | N/A | N/A | 08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189, 198, 220 | N/A |
Vaccine Dose Parameters - Minimum and Recommended Intervals
Doses | Series Name | Absolute Minimum Interval | Minimum Interval | Recommended Interval | Latest Recommended Interval (less than) |
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Dose 1 to 2 | Hep B 3-dose Adult Series | 24 days | 28 days | 28 days | N/A |
Dose 2 to 3 | Hep B 3-dose Adult Series | 8 weeks - 4 days | 8 weeks | 8 weeks | N/A |
Dose 1 to 3 | Hep B 3-dose Adult Series | 16 weeks - 4 days | 16 weeks | 6 months | N/A |
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Series Special Rules HEPLISAV-B (CVX 189) Exception Rule - A series containing 2 doses of HEPLISAV-B (CVX 189) administered at least minimum interval 4 weeks (absolute minimum interval = 24 days) apart is complete, regardless of any other Hep B shots administered (before, in between). For the non-CVX 189 shots, evaluate as Accepted and the reason code is VACCINE_NOT_COUNTED_BASED_ON_MOST_RECENT_VACCINE_GIVEN.
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- For the purpose of evaluation of the non-CVX 189 administered vaccines, ignore the non-CVX 189 shots.
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