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Table of Contents

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Rules Based on Patient's Age

  • If a patient is >= 60 years old and did NOT get a shot of Hep B, then the Recommendation is Conditional and the reason code is HIGH_RISK
  • Shots administered to a patient who is >= 60 years of age will continue to be evaluated and, if valid, will count toward completion of the series.

Proof of Immunity Rules

  • If a patient has immunity (reported as having a positive titer or serology) vaccine is not recommended.
  • Any shot administered prior to the date of immunity is evaluated as Valid or Invalid, based on minimum age and minimum interval rules.
  • Any shot administered on or after the date of immunity is evaluated as Accepted with a reason code of PROOF_OF_IMMUNITY; Recommendation is Not Recommended and the reason code is PROOF_OF_IMMUNITY.

Atkinson (Enough is Enough) Rule

  • If a patient receives target dose 3 that is invalid (e.g. due to minimum interval violation or minimum age violation), there is no minimum interval between the next-to-last shot (invalid shot) and dose 3 (the final dose), but the patient must a.) meet the minimum interval between dose 2 and the final dose (52 days), b.) meet the minimum age for the final dose in the series (164 days), and c.) meet the minimum interval between dose 1 and dose 3 of 16 weeks. 
    • Example: Dose 1 at 28 days, dose 2 at 113 days, invalid shot 3 (target dose 3) at 163 days (below minimum age for the series and below minimum interval), shot 4/dose 3 at 165 days = series complete (even though there is only a 2-day interval between shot 3 and shot 4/dose 3), based on the Atkinson Rule.
  • The Atkinson rule does not apply to recommendations; when determining the date due the recommended interval is calculated from the last shot given.

Select Adjuvant Product Interval

Rules for Recommending at the CVX Code vs. Vaccine Group Level

  • When recommending in the Hep B 3-dose Newborn Series, the Hep B 3-dose Child/Adolescent Series, or the Hep B 3-dose Adult Series, recommend at the vaccine group level.
  • When recommending in the Hep B 2-dose Adult Series, recommend at the CVX level; vaccine recommended should be CVX 189 (Hep B, adjuvanted).

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Doses

Series Name

Absolute Minimum Interval

Minimum Interval

Minimum Recommended Interval

Latest Recommended Interval (less than)

Dose 1 to 2

Hep B 3-dose Child/Adolescent Series

24 days

28 days

28 days (4 weeks)

N/A

Dose 2 to 3

Hep B 3-dose Child/Adolescent Series

52 days

56 days

56 days (8 weeks)

N/A

Dose 1 to 3

Hep B 3-dose Child/Adolescent Series

108 days

112 days

112 days (16 weeks)

N/A

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Doses

Series Name

Absolute Minimum Interval

Minimum Interval

Minimum Recommended Interval

Latest Recommended Interval (less than)

Dose 1 to 2

Hep B 2-dose Adult Series

24 days

28 days

28 days (4 weeks)

56 days (8 weeks)

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Immunization Series: Hep B 3-dose Adult Series

The Hep B 3-dose Adult Series is complete after 3 doses.

Vaccine Dose Parameters - Minimum and Routine Ages

Dose

Series Name

Absolute Minimum
 Age 

Minimum Age

Routine
Age 

Latest Recommended Age (less than)Valid CVX Code(s) per Dose for this SeriesInvalid CVX Code(s) per Dose for this Series

1

Hep B 3-dose Adult Series

19 years

19 years

19 years

N/A08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189, 198, 220N/A

2

Hep B 3-dose Adult Series

N/A

N/A

N/A

N/A08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189, 198, 220N/A
3Hep B 3-dose Adult SeriesN/AN/AN/AN/A08, 42, 45, 43, 44, 51, 110, 104, 102, 132, 146, 189, 198, 220N/A

Vaccine Dose Parameters - Minimum and Recommended Intervals

Doses

Series Name

Absolute Minimum Interval

Minimum Interval

Minimum Recommended Interval

Latest Recommended Interval (less than)

Dose 1 to 2

Hep B 3-dose Adult Series

24 days

28 days

28 days 

N/A
Dose 2 to 3Hep B 3-dose Adult Series8 weeks - 4 days8 weeks8 weeksN/A
Dose 1 to 3Hep B 3-dose Adult Series16 weeks - 4 days16 weeks6 monthsN/A


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Series Special Rules 

HEPLISAV-B (CVX 189) Exception Rule

  • A series containing 2 doses of HEPLISAV-B (CVX 189) administered at least minimum interval 4 weeks (absolute minimum interval = 24 days) apart is complete, regardless of any other Hep B shots administered (before, in between). For the non-CVX 189 shots, evaluate as Accepted and the reason code is VACCINE_NOT_COUNTED_BASED_ON_MOST_RECENT_VACCINE_GIVEN. For the purpose of evaluation of the non-CVX 189 administered vaccines, ignore the non-CVX 189 shots.