Table of Contents

RSV Vaccine Group Evaluation and Forecasting Rules

General Rules for RSV

General rules are not series-specific; general rules apply to the entire vaccine group.

Rules Based on Patient Age

Recommendation Rules

If a patient is < 8 months,
- and is not complete for the RSV Infant Series,
  - and is not in the RSV season as of the evaluation date,
    - and will be < 8 months at the next RSV season start date, the recommendation is Future Recommended with reason code SUPPLEMENTAL_TEXT, descriptive text, "If the mother of the patient was not vaccinated during her pregnancy, her vaccination status is unknown, or she was vaccinated within 14 days of the patient birth, then administer RSV mAb dose based on patient weight shortly before or during the RSV season."
    - and will be >= 8 months at the next RSV season start date, the recommendation is Conditional with reason code HIGH_RISK.
  - and is in the RSV season as of the evaluation date, the recommendation is Recommended with reason code SUPPLEMENTAL_TEXT, descriptive text, "If the mother of the patient was not vaccinated during her pregnancy, her vaccination status is unknown, or she was vaccinated within 14 days of the patient birth, then administer RSV mAb dose based on patient weight shortly before or during the RSV season."
- and is complete for the RSV Infant Series, the recommendation is Not Recommended and the reason code is COMPLETE_HIGH_RISK.
If a patient is >= 8 months and < 20 months, the recommendation is Conditional and the reason code is HIGH_RISK.
If a patient is >= 20 months and < 60 years old,
- and is not complete for the RSV Adult Series, the recommendation is Future Recommended with reason code SUPPLEMENTAL_TEXT with descriptive text, "The RSV evaluations and recommendations in ICE primarily target the routine series. RSV is recommended as a single lifetime dose for all adults 75 years of age and older and adults 60 through 74 years of age and older who are at increased risk of severe RSV disease. Note: RSV vaccine is also recommended for pregnant persons at 32 through 36 weeks gestation, using seasonal administration."
- and is complete for the RSV Adult Series, the recommendation is Not Recommended with the reason code COMPLETE.
If a patient is >= 60 years old and < 75 years old,
- and is not complete for the RSV Adult Series, the recommendation is Conditional with reason codes HIGH_RISK and SUPPLEMENTAL_TEXT with descriptive text, "The RSV evaluations and recommendations in ICE primarily target the routine series. RSV is recommended as a single lifetime dose for all adults 75 years of age and older and adults 60 through 74 years of age who are at increased risk of severe RSV disease."
- and is complete for the RSV Adult Series, the recommendation is Not Recommended with the reason code COMPLETE.
If a patient is >= 75 years old,
- and is not complete for the RSV Adult Series, the recommendation is Recommended.
- and is complete for the RSV Adult Series, the recommendation is Not Recommended with the reason code COMPLETE.
The first season of the RSV Infant Series started on 10/1/2023. Therefore, the earliest recommendation date for an RSV dose in the Infant Series is 10/1/2023.
The recommended date for the RSV Adult Series is the later of the calculated forecast date or June 26, 2024.

Evaluation of Shots Administered at age >= 8 months and < 50 years

If any RSV shot is administered at age >= 8 months and < 50 years, evaluate the shot as Accepted / OUTSIDE_ROUTINE_SERIES.
- Note: This rule overrides the ICE General Rule "Evaluation Selection Priority" in all cases, except where the ICE General Rule "Evaluation of Shots Above the Vaccine Code Absolute Maximum Age" applies.

RSV Vaccines

CVX Code	Name	Absolute Maximum Age
303	RSV, recombinant (Adult)
304	Respiratory syncytial virus (RSV), unspecified
305	RSV, bivalent, PF (Adult)
306	RSV, mAb, 0.5 mL, age 0 - < 8 mos.	24 months - 1 day
307	RSV, mAb, 1 mL, age 0 - 19 mos.	24 months - 1 day
314	Respiratory syncytial virus (RSV) vaccine, unspecified
315	Respiratory syncytial virus (RSV) MAB, unspecified	24 months - 1 day
326	RSV, mRNA, injectable, PF

Combination Vaccines that Include RSV

No combination vaccines exist, at this time, that include RSV.

CVX Code Specific Rules

CVX Code Absolute Maximum Age

If one of the CVX codes in the table above is administered above the absolute maximum age for that CVX code, then the Evaluation is Invalid and the reason code is ABOVE_MAXIMUM_AGE_VACCINE, per the ICE General Rule "Evaluation of Shots Above the Vaccine Code Absolute Maximum Age".

Immunization Series and Selection Rules

Series Name

RSV Infant Series
RSV Adult Series

Series Selection Rules

There are two series for this vaccine group: the RSV Infant Series and the RSV Adult Series. The rules for determining which series applies are:

If a patient is < 20 months, then the RSV Infant Series applies.
If a patient is >= 20 months, then the RSV Adult Series applies.

Immunization Series: RSV Infant Series

Vaccine Dose Parameters - Minimum and Routine Ages

Dose	Series Name	Absolute Minimum Age	Minimum Age	Routine Age	Latest Recommended Age (less than)	Valid CVX Code(s) per Dose for this Series	Invalid CVX Code(s) per Dose for this Series
1	RSV Infant Series	0 days	0 days	0 days	N/A	304, 306, 307, 315	303, 305, 314, 326

Series Special Rules

Infant RSV Season Rules

Infant RSV Season Start and End Dates
- The infant RSV season default start date is October 1 and the default end date is March 31. The default start date for the next infant RSV season is October 1.
Recommendation and Recommended Due Date
- Infant RSV is due only during the defined RSV season.
  - Note, the earliest date and the recommended date will be when the patient age 0 days to < 8 months is in the infant RSV season.
Evaluation
- RSV shots¹ administered to a patient age < 8 months outside the RSV season (e.g., during September, if the season has been defined as October 1 to March 31) will be evaluated as Valid with reason code OUTSIDE_SEASON. (Note: Patient is complete for the RSV Infant Series.)²
- There is no absolute minimum interval between shots administered outside the RSV season and target dose 1 of the next RSV season.
- If an RSV shot is administered at age < 8 months, and after the series is complete, then evaluate the shot as Accepted with a reason code of EXTRA_DOSE.

RSV Infant Series Invalid CVX Code for Dose Rule

If CVX codes listed in the "Invalid CVX Code(s) per Dose for this Series" are administered as a target dose in the RSV Infant Series, then the Evaluation is Invalid and the reason code is VACCINE_NOT_ALLOWED_FOR_THIS_DOSE, per the ICE General Rule "Evaluation of Shots Identified as an Invalid CVX Code Per Dose for a Series". Ignore the shot when determining the recommended vaccine and calculating the recommended due date for the next target dose.

RSV Shots Administered Prior to 8/3/2023

If an infant RSV vaccine (CVX 304, CVX 306, CVX 307, CVX 315) is administered prior to 8/3/2023, evaluate the shot as Invalid with reason code VACCINE_NOT_YET_AVAILABLE_ON_DATE_SPECIFIED.

Notes

¹Shots need to be listed as valid CVX codes per dose to be considered Valid.
²Although administration is recommended in the infant RSV season, doses administered outside the season are valid per CDC Guidance and CDSi.

Immunization Series: RSV Adult Series

Vaccine Dose Parameters - Minimum and Routine Ages

Dose	Series Name	Absolute Minimum Age	Minimum Age	Routine Age	Latest Recommended Age (less than)	Valid CVX Code(s) per Dose for this Series	Invalid CVX Code(s) per Dose for this Series
1	RSV Adult Series	50 years³	75 years	75 years	N/A	303, 304, 305, 314, 326	306, 307, 315

Series Special Rules

RSV Adult Series Invalid CVX Code for Dose Rule

If CVX codes listed in the "Invalid CVX Code(s) per Dose for this Series" are administered as a target dose in the RSV Adult Series, then the Evaluation is Invalid and the reason code is VACCINE_NOT_ALLOWED_FOR_THIS_DOSE, per the ICE General Rule "Evaluation of Shots Identified as an Invalid CVX Code Per Dose for a Series". Ignore the shot when determining the recommended vaccine and calculating the recommended due date for the next target dose.

RSV Shots Administered Prior to 6/21/2023

If an adult or otherwise unspecified RSV vaccine (CVX 303, CVX 304, CVX 305, CVX 314, CVX 326) is administered prior to 6/21/2023, evaluate the shot as Invalid with reason code VACCINE_NOT_YET_AVAILABLE_ON_DATE_SPECIFIED.

Notes

³The RSV Adult Series absolute minimum age of 50 years aligns with CDSi and CDC CDSi SME guidance indicating not to repeat a dose given to a patient age >=50 years and < 75 years.

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