Orthopoxvirus Vaccine Group - May 2022 Emergency Use Authorization (EUA) for Monkeypox


Table of Contents

Orthopoxvirus Vaccine Group Evaluation and Forecasting Rules

General Rules for Orthopoxvirus - EUA

General rules are not series-specific; general rules apply to the entire vaccine group.

If the patient has no dose (valid shot) on record, recommendation is Conditional with reason code HIGH_RISK.

Orthopoxvirus Vaccines

CVX Code

Name

Absolute Minimum Age

751

vaccinia (smallpox) vaccine (ACAM2000)

1 year - 4 days

1051

vaccinia (smallpox) vaccine, diluted (Inactive; not preferred)

1 year - 4 days

2061

Vaccinia, smallpox monkeypox vaccine live, PF (JYNNEOS)

0 days

Combination Vaccines that Include Orthopoxvirus

No combination vaccines exist, at this time, that include Orthopoxvirus.


CVX Code Specific Rules

Immunization Series and Selection Rules - EUA

Series Name

  • Monkeypox 2-Dose Series - EUA - May 2022
  • Monkeypox 1-Dose Series - EUA - May 2022

Series Selection Rules

There are two series for this vaccine group: the Monkeypox 2-Dose Series and the Monkeypox 1-Dose Series. The rules for determining which series applies are:

  • If a CVX 75 or CVX 105 dose is administered for dose 1, the Orthopoxvirus 1-Dose Series (May 2022 EUA) applies.

  • If a CVX 206 dose is administered for dose 1, the Orthopoxvirus 2-Dose Series (May 2022 EUA) applies. 

Immunization Series: Orthopoxvirus 2-Dose Series (May 2022 EUA)

The Orthopoxvirus 2-Dose Series - EUA - May 2022 is complete after 2 doses.

Vaccine Dose Parameters - Minimum and Routine Ages 

Dose

Series Name

Absolute Minimum
 Age

Minimum Age

Routine
Age 

Latest Recommended Age (less than)Valid CVX Code(s) per Dose for this SeriesInvalid CVX Code(s) per Dose for this Series

1

Orthopoxvirus 2-Dose Series (May 2022 EUA)

0 days

18 years

18 years

N/A206
N/A

2

Orthopoxvirus 2-Dose Series (May 2022 EUA)

N/A

N/A

N/A

N/A206, 75, 105N/A

Vaccine Dose Parameters - Minimum and Recommended Intervals

Doses

Series Name

Absolute Minimum Interval

Minimum Interval

Minimum Recommended Interval

Latest Recommended Interval (less than)

Dose 1 to 2

Orthopoxvirus 2-Dose Series (May 2022 EUA)

0 days

28 days

28 days

35 days

Series Special Rules 

Series Evaluation Special Rules

  • The series is complete after 2 doses.

  • If the 2nd shot is administered below the minimum interval or live virus interval, evaluate the shot as Valid with reason code SUPPLEMENTAL_TEXT and descriptive text: “The interval between this dose and the prior shot is less than the minimum interval. The dose does not need to be repeated unless the patient is severely immunosuppressed, in which case the repeated dose should be administered after the dose given in error by at least 28 days.”

  • If an additional shot is administered after the series is complete, evaluate it as Valid. Evaluate all additional shots afterwards as Accepted / EXTRA_DOSE.

Immunization Series: Orthopoxvirus 1-Dose Series (May 2022 EUA)

The Monkeypox 1-Dose Series - EUA - May 2022 is complete after 1 dose.

Vaccine Dose Parameters - Minimum and Routine Ages

Dose

Series Name

Absolute Minimum
 Age 

Minimum Age

Routine
Age 

Latest Recommended Age (less than)Valid CVX Code(s) per Dose for this SeriesInvalid CVX Code(s) per Dose for this Series

1

Orthopoxvirus 1-Dose Series (May 2022 EUA)

1 year - 4 days

N/A

N/A

N/A75, 105
N/A

Series Special Rules

Series Evaluation Special Rules

  • The series is complete after 1 dose.

  • If an additional shot is administered after the series is complete, evaluate it as Valid. Evaluate all additional shots afterwards as Accepted / EXTRA_DOSE.