HPV Vaccine Group

Table of Contents

HPV Vaccine Group Evaluation and Forecasting Rules

General Rules for HPV

General rules are not series-specific; general rules apply to the entire vaccine group.

Rules Based on Patient's Age

For males and females:

  • If a patient is < 27 years old, follow the Immunization Series and Selection Rules (listed below).
  • If a patient is >= 27 years and < 46 years old and:
    • Has one or more doses at < 46 years old, has not completed the series, and will be < 46 years old at the next recommended due date, then recommend based on table rules. 
    • Does NOT have any doses at < 46 years old, then Recommendation is Conditional and the reason code is CLINICAL_PATIENT_DISCRETION.
    • Shots administered to a patient who is >= 27 years and < 46 years will continue to be evaluated (based on minimum intervals) and, if valid, will count toward completion of the series.
  • If the patient is >= 46 years old, (or will be >= 46 years old at the next recommended due date), then:
    • Recommendation is Not Recommended and the reason code is TOO_OLD. 
    • If a dose is administered at >= 46 years, the Evaluation is Accepted and the reason code is ABOVE_REC_AGE_SERIES.
    • The series can NOT be initiated and completed once the patient is >= 46 years old.

Rules for Recommending at the CVX Code vs. Vaccine Group Level

  • When recommending in the HPV 3-dose series or HPV 2-dose series, always recommend at the vaccine group level.

HPV Vaccines

CVX Code

Name

62

HPV, quadrivalent (Gardasil)

118

HPV, bivalent (Cervarix)

137

HPV, unspecified formulation

165HPV9

CVX Code Specific Rules

Rule for CVX 118 (HPV, bivalent (Cervarix)

  • CVX 118 is not licensed for use in males. If CVX 118 (HPV, bivalent (Cervarix) is reported for a male patient, then evaluate as Accepted and the reason code is VACCINE_NOT_LICENSED_FOR_MALES. Ignore the reported CVX 118 when determining the recommended vaccine and calculating the recommended due date for the next target dose.

Combination Vaccines that Include HPV

No combination vaccines exist, at this time, that include HPV.

Immunization Series and Selection Rules

Series Name

  • HPV 2-dose Series
  • HPV 3-dose Series

Series Selection Rules

The HPV 2-dose series applies if any one of the following is true:

  • If the patient < 15 years old and no doses have been administered
  • If dose 1 was administered and is given to a patient >= 9 years - 4 days old and < 15 years old
  • If dose 1 was administered and is given to a patient >= 9 years - 4 days old and < 15 years old and
    • target dose 2 is valid for the HPV 2-dose series, the HPV 2-dose series applies.
    • target dose 2 is invalid or accepted for the HPV 2-dose series, but valid for HPV 3-dose series, the HPV 3-dose series applies. (Note: Once the 3-dose series is triggered, it cannot switch back to applying the 2-dose series.)
    • target dose 2 is invalid or accepted for BOTH the HPV 2-dose series and HPV 3-dose series, the HPV 2-dose series applies.

Otherwise, the HPV 3-dose series applies.

Immunization Series: HPV 2-dose Series

The HPV 2-dose series is complete after 2 doses.

Vaccine Dose Parameters - Minimum and Routine Ages 

Dose

Series Name

Absolute Minimum
 Age

Minimum Age

Routine
Age 

Latest Recommended Age (less than)

Valid CVX Code(s)

per Dose for this Series

Invalid CVX Code(s)

per Dose for this Series

1

HPV 2-dose

9 years - 4 days

9 years

11 years

13 years + 4 weeks62, 118, 137, 165

N/A

2

HPV 2-dose

N/A

N/A

N/A

N/A62, 118, 137, 165
N/A

Vaccine Dose Parameters - Minimum and Recommended Intervals 

Doses

Series Name

Absolute Minimum Interval

Minimum Interval

Recommended Interval

Latest Recommended Interval (less than)

Dose 1 to 2

HPV 2-dose

5 months - 4 days

5 months

6 months

13 months + 4 weeks

Series Special Rules 

  • There are no special rules for this series. 

Immunization Series: HPV 3-dose Series

The HPV 3-dose series is complete after 3 doses.

Vaccine Dose Parameters - Minimum and Routine Ages

Dose

Series Name

Absolute Minimum
 Age

Minimum Age

Routine
Age 

Latest Recommended Age (less than)Valid CVX Code(s) per Dose for this SeriesInvalid CVX Code(s) per Dose for this Series

1

HPV 3-dose

 9 years - 4 days

9 years

11 years

If Patient age < 15 years: 13 years + 4 weeks

If Patient age >= 15 years: 15 years

 62, 118, 137, 165
 N/A

2

HPV 3-dose

N/A

N/A

N/A

N/A 62, 118, 137, 165
 N/A

3

HPV 3-dose

N/A

N/A

N/A

N/A 62, 118, 137, 165
 N/A

Vaccine Dose Parameters - Minimum and Recommended Intervals

Doses

Series Name

Absolute Minimum Interval

Minimum Interval

Recommended Interval

Latest Recommended Interval (less than)

Dose 1 to 2

HPV 3-dose

24 days

28 days

4 weeks

If Dose 1 administered at age < 15 years: 13 months + 4 weeks

If Dose 1 administered at age >= 15 years: 16 weeks

Dose 2 to 3

HPV 3-dose

80 days

84 days

4 months

N/A
Dose 1 to 3HPV 3-dose5 months - 4 days168 days6 months

If Dose 1 administered at age < 15 years: 13 months + 4 weeks

If Dose 1 administered at age >= 15 years: 7 months + 4 weeks

Series Special Rules 

  • There are no special rules for this series.