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Rules Based on Patient's Age

• If a patient is >= 19 years old and did NOT get a shot of Hep B, then the Recommendation is Conditional and the reason code is HIGH_RISK. 
• Shots administered to a patient who is >= 19 years of age will continue to be evaluated and, if valid, will count toward completion of the series.

Proof of Immunity Rules

• If a patient has immunity (reported as having a positive titer or serology) vaccine is not recommended.
• Any shot administered prior to the date of immunity is evaluated as Valid or Invalid, based on minimum age and minimum interval rules.
• Any shot administered on or after the date of immunity is evaluated as Accepted with a reason code of PROOF_OF_IMMUNITY; Recommendation is Not Recommended and the reason code is PROOF_OF_IMMUNITY.
  

Atkinson (Enough is Enough) Rule

• If a patient receives target dose 3 that is invalid (e.g. due to minimum interval violation or minimum age violation), there is no minimum interval between the next-to-last shot (invalid shot) and dose 3 (the final dose), but the patient must a.) meet the minimum interval between dose 2 and the final dose (52 days), b.) meet the minimum age for the final dose in the series (164 days), and c.) meet the minimum interval between dose 1 and dose 3 of 16 weeks. 
  
  • Example: Dose 1 at 28 days, dose 2 at 113 days, invalid shot 3 (target dose 3) at 163 days (below minimum age for the series and below minimum interval), shot 4/dose 3 at 165 days = series complete (even though there is only a 2-day interval between shot 3 and shot 4/dose 3), based on the Atkinson Rule.
• The Atkinson rule does not apply to recommendations; when determining the date due the recommended interval is calculated from the last shot given.

Select Adjuvant Product Interval

• The Select Adjuvant Product Interval rule applies to CVX 189. For rule details, see the Select Adjuvant Product Interval rule on the General ICE Rules page.

Rules for Recommending at the CVX Code vs. Vaccine Group Level

• When recommending in the Hep B 3-dose Newborn Series or Hep B 3-dose Child/Adult Series, always recommend at the vaccine group level.
• When recommending in the Hep B 2-dose Adult Series, always recommend at the CVX level; vaccine recommended should be CVX 189 (Hep B, adjuvanted).

CVX Code Specific Rules

CVX Code Maximum Age

• CVX 08 (Hep B, adolescent or pediatric) and CVX 42 (Hep B, adolescent/high risk infant) will be evaluated as follows:
  
  • Invalid/ INSUFFICIENT_ANTIGEN if administered to a patient who is >= 20 years old.
  • Valid (as long as minimum interval/minimum age requirements are met, where applicable) if administered to a patient who is < 20 years old.

Series Special Rules 

HEPLISAV-B (CVX 189) Exception Rule

• A series containing 2 doses of HEPLISAV-B (CVX 189) administered at least minimum interval 4 weeks (absolute minimum interval = 24 days) apart is complete, regardless of any other Hep B shots administered (before, in between). For the non-CVX 189 shots, evaluate as Accepted and the reason code is VACCINE_NOT_COUNTED_BASED_ON_MOST_RECENT_VACCINE_GIVEN. For the purpose of evaluation of the non-CVX 189 administered vaccines, ignore the non-CVX 189 shots. 
  • Note: All shots given after a series is complete should be evaluated according to the ICE General Rule "Shots Administered After Series is Complete".

Series Special Rules 

Adolescent 2-Dose Series Rules

• If a.) CVX 43 (Hep B adult) is administered to a patient >= 11 years and < 16 years as dose 1 and dose 2 AND b.) there is a minimum interval of 4 months - 4 days between dose 1 and dose 2, THEN the series is complete with 2 doses. If this rule is not met, default to the 3-dose series.
• If a patient >= 11 years and < 16 years is administered CVX 43 (Hep B adult) as shot 1, shot 2 will be recommended based on the Child/Adult series, NOT the Adolescent 2-Dose Series Rule.

HEPLISAV-B (CVX 189) Exception Rule

• A series containing 2 doses of HEPLISAV-B (CVX 189) administered at least minimum interval 4 weeks (absolute minimum interval = 24 days) apart is complete, regardless of any other Hep B shots administered (before, in between). For the non-CVX 189 shots, evaluate as Accepted and the reason code is VACCINE_NOT_COUNTED_BASED_ON_MOST_RECENT_VACCINE_GIVEN. For the purpose of evaluation of the non-CVX 189 administered vaccines, ignore the non-CVX 189 shots. 
  • Note: All shots given after a series is complete should be evaluated according to the ICE General Rule "Shots Administered After Series is Complete".

Series Special Rules 

HEPLISAV-B (CVX 189) Exception Rule

• A series containing 2 doses of HEPLISAV-B (CVX 189) administered at least minimum interval 4 weeks (absolute minimum interval = 24 days) apart is complete, regardless of any other Hep B shots administered (before, in between). For the non-CVX 189 shots, evaluate as Accepted and the reason code is VACCINE_NOT_COUNTED_BASED_ON_MOST_RECENT_VACCINE_GIVEN. For the purpose of evaluation of the non-CVX 189 administered vaccines, ignore the non-CVX 189 shots. 
  • Note: All shots given after a series is complete should be evaluated according to the ICE General Rule "Shots Administered After Series is Complete".